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Ecotin is a serine protease inhibitor that is found in the periplasm of Escherichia coli. It has a very broad range of inhibition including the pancreatic serine proteases trypsin and chymotrypsin, human leukocyte, porcine elastase, and rat mast cell chymase. Ecotin is regarded as a potent, tight-binding, reversible inhibitor of Factor Xa. Ecotin does not inhibit the human plasma proteases thrombin, tissue Factor VIIa, Factor XIa, Protein C, plasmin or tPA.References
1. Seymour, J.L. et al. (1994) Biochemistry 33:3949-3958.