| 產(chǎn)品名稱 | ML 323 |
| 產(chǎn)品貨號(hào) | Axon 2309 CAS [1572414-83-5] MF C23H24N6MW 384.48 Purity: 100% Soluble in DMSO Description Selective, reversible and highly potent inhibitor of the USP1–UAF1 deubiquitinase complex that links deubiquitination to DNA damage responses (IC50 values of 76 nM in a ubiquitin-rhodamine (Ub-Rho) assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively). ML323 effectively sensitized cisplatin-resistant NSCLC H596 cells and U2OS osteosarcoma cells to cisplatin since it simultaneously targets two major DNA damage response pathways (TLS and FA) by inhibiting a common deubiquitinase. KEYWORDS: ML 323 | USP1-UAF1 inhibitor | ML323 |CAS[1572414-83-5] | Ubiquitin peptides | Deubiquitinase | Inhibitor | DNA damage | ?cisplatin-resistant | TLS | FA |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
ML 323Axon 2309 CAS [1572414-83-5] MF C23H24N6
DescriptionSelective, reversible and highly potent inhibitor of the USP1–UAF1 deubiquitinase complex that links deubiquitination to DNA damage responses (IC50 values of 76 nM in a ubiquitin-rhodamine (Ub-Rho) assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively). ML323 effectively sensitized cisplatin-resistant NSCLC H596 cells and U2OS osteosarcoma cells to cisplatin since it simultaneously targets two major DNA damage response pathways (TLS and FA) by inhibiting a common deubiquitinase. KEYWORDS: ML 323 | USP1-UAF1 inhibitor | ML323 |CAS[1572414-83-5] | Ubiquitin peptides | Deubiquitinase | Inhibitor | DNA damage | ?cisplatin-resistant | TLS | FA
Selective, reversible and potent inhibitor of the USP1–UAF1 deubiquitinase complex
Chemical nameN-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine Parent CAS No.[1572414-83-5] |
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