產品名稱

U 0126 - U 126

產品貨號

Axon 2520 CAS [109511-58-2] MF C18H16N6S2MW 380.49 Purity: 99% Soluble in DMSO and Ethanol Description Non-competitive inhibitior of the dual specificity kinase MEK (IC50 values 0.07 μM and 0.06 μM for MEK1 and MEK2, respectively) that protects the brain against damage resulting from ischemic stroke in mice. U0126 is frequently used in combination with PD 98059 (Axon 1223), and both are found to accelerate differentiation of murine RAW264.7 cells into osteoclast-like cells. KEYWORDS: U 0126 | Supplier | MEK1/2 inhibitor | U 126 | U0126 | U126 | CAS [109511-58-2] | ?[1173097-76-1] | MAPK | MEK | Inhibitor | Ischemia | stroke | differentiation | osteoclast-like cells

產品價格

現貨詢價，電話：010-67529703

產品規格

產品品牌

axonmedchem

產品概述

產品詳情

U 0126 - U 126

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2520

CAS [109511-58-2]

MF C18H16N6S2
MW 380.49

Purity: 99%
Soluble in DMSO and Ethanol

U 0126

Description

Non-competitive inhibitior of the dual specificity kinase MEK (IC50 values 0.07 μM and 0.06 μM for MEK1 and MEK2, respectively) that protects the brain against damage resulting from ischemic stroke in mice. U0126 is frequently used in combination with PD 98059 (Axon 1223), and both are found to accelerate differentiation of murine RAW264.7 cells into osteoclast-like cells.

J.V. Duncia et al. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2839-44.

H. Hotokezaka et al. U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. J Biol Chem. 2002 Dec 6;277(49):47366-72.

M.F. Favata et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273(29):18623-32.

S. Namura et al. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11569-74.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS Stem Cell MAPK EC 2.7.12.2 MEK

Non-competitive inhibitor of MEK1/2 and protects brain in stroke models

Chemical name

2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile

Parent CAS No.

[109511-58-2]

產品資料

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U 0126 - U 126

Description

Chemical name

Parent CAS No.