| 產品名稱 | Recombinant Human R-Spondin 2 (Carrier-free), Tonbo Biosciences |
| 產品貨號 | 21-7127-U005 |
| 產品價格 | 現貨詢價，電話：010-67529703 |
| 產品規格 | |
| 產品品牌 | vwr |
| 產品概述 | |
| 產品詳情 |
R-Spondin 2 (RSPO2) is a secreted protein belonging to the R-Spondin family of four structurally related Wnt/beta-catenin signaling regulators. All four members contain one thrombospondin-like and two furin-like domains. In adults, R-Spondin 2 is expressed in intestine and lung as well as other organs of endodermal origin. R-Spondins can enhance Wnt/beta-catenin signaling as they compete with the Wnt agonist DKK-1 for binding to Wnt co-receptors LRP6/Kremen. They can also act as a signaling activation ligand on LRP6 and LGR4 to form a cluster with WNT and FZD. The R-Spondins have been demonstrated to bind to LGR-4, LGR-5 and LGR-6 receptors with high affinity.
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