| 產品名稱 | TH 5487 |
| 產品貨號 | Axon 2934 CAS [2304947-71-3] MF C19H18BrIN4O2MW 541.18 Purity: 98% Soluble in DMSO Recently added |
| 產品價格 | 現貨詢價，電話：010-67529703 |
| 產品規格 | |
| 產品品牌 | axonmedchem |
| 產品概述 | |
| 產品詳情 |
TH 5487Axon 2934 CAS [2304947-71-3] MF C19H18BrIN4O2
Recently added
DescriptionTH 5487 is a potent and selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with an IC50 of 342 nM. TH 5487 inhibited DNA repair and modified OGG1 chromatin dynamics, which resulted in the inhibition of proinflammatory pathway genes. Furthermore, TH 5487 was well tolerated by mice and suppressed lipopolysaccharide- and tumor necrosis factor–α–mediated neutrophilic inflammation in the lungs. KEYWORDS: TH 5487 | supplier | OGG1 inhibitor | TH5487 | TH-5487 | CAS [2304947-71-3] | Glycosides | OGG1 | Inhibitor | Enzymes
Potent and selective active-site OGG1 inhibitor
Chemical name4-(4-Bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide Parent CAS No.[2304947-71-3] |
| 產品資料 |
