| 產品名稱 | GW 2580 |
| 產品貨號 | Axon 2571 CAS [870483-87-7] MF C20H22N4O3MW 366.41 Purity: 99% Soluble in DMSO Description An orally bioavailable inhibitor of c-FMS kinase (IC50 value of 0.03 μM in vitro) and the CSF1R receptor (Kd value 1.6 nM) that competitively blocks the ATP binding site of c-FMS. GW 2580 was inactive against 26 kinases in vitro and did not inhibit the growth of mouse NS0 lymphoblastoid cells, human fibroblasts, human endothelial cells, and five human tumor cell lines. GW 2580 also interacts with TrkA, TrkB, and TrkC (Kd values 630 nM, 36 nM, and 120 nM, respectively) KEYWORDS: GW 2580 | supplier | dual cFMS kinase/CSF1R inhibitor | GW2580 | GW-2580 | CAS [870483-87-7] | FLT3LG | FMS | Inhibitor |RTK| c-FMS| CSF1R | FLT3 | ATP binding site | TrkA | TrkB | TrkC |
| 產品價格 | 現貨詢價，電話：010-67529703 |
| 產品規格 | |
| 產品品牌 | axonmedchem |
| 產品概述 | |
| 產品詳情 |
GW 2580Axon 2571 CAS [870483-87-7] MF C20H22N4O3
DescriptionAn orally bioavailable inhibitor of c-FMS kinase (IC50 value of 0.03 μM in vitro) and the CSF1R receptor (Kd value 1.6 nM) that competitively blocks the ATP binding site of c-FMS. GW 2580 was inactive against 26 kinases in vitro and did not inhibit the growth of mouse NS0 lymphoblastoid cells, human fibroblasts, human endothelial cells, and five human tumor cell lines. GW 2580 also interacts with TrkA, TrkB, and TrkC (Kd values 630 nM, 36 nM, and 120 nM, respectively) KEYWORDS: GW 2580 | supplier | dual cFMS kinase/CSF1R inhibitor | GW2580 | GW-2580 | CAS [870483-87-7] | FLT3LG | FMS | Inhibitor |RTK| c-FMS| CSF1R | FLT3 | ATP binding site | TrkA | TrkB | TrkC
Orally bioavailable inhibitor of cFMS kinase and CSF1R
Chemical name5-(3-methoxy-4-(4-methoxybenzyloxy)benzyl)pyrimidine-2,4-diamine Parent CAS No.[870483-87-7] |
| 產品資料 |
